From my reasoning if you ran a dual 2ohm and dual 4 ohm subs in parallel of the same make and power handling it would give you a .75 load. Would there be something hindering me from dueing this as long as my amp can handle the load?

dont mix subs of different impedences, they wont get the same amount of wattage which can cause problems with cancellation

^ what he said

Thanks fellas.