I'm looking to build clean boxes of mids/highs and a woofer in a waist high tower.  I was going to throw matching pairs of infinity 6.5s, 5.25s, and 10" unknowns in 2 towers and an RE XXX v3 in a woofer tower. 

 

Before I start building, what do I need as far as crossovers go to connect my mids highs to a 4/8 ohm load.  looking to run a 400 watt receiver and a separate amp for the woofer.  ANy good equip I can look for?  Any recommendations for build or getting started?  type of wood that looks really clean?

building your own crossovers yields best results... but PE has lots pre-built with great quality/pricing

You are putting ALL of those drivers in a tower?  If so that is a recipe for disaster.  

 

Anything more than a 2 way will be EXTREMELY hard for you to build a crossover for.  Far from trivial.  And, no, you can't just buy a crossover and even have mediocre results.

Check out some proven designs and build them, you will be much happier and learn.  There are tons of big tower type designs out there.  I am building a set of Adire Hurricane knock-offs with some different 18" woofers, super loud and will sound good.  By copying 90% of Adire's design and just tailoring one part of the crossover for my different 18's I saved myself a bunch of design/eval time.  But even with a mod this small, I still have to test and measure to make sure everything is OK.

 

Designing a proper passive crossover is the hardest part of loudspeaker design.  A simple 2-way takes a lot of work to get right.  Like M5 said, the pre-made universal ones suck.  They keep you from blowing drivers, that is about it...