I have a problem with my mtx 12s everything is hooked up but when I press the gas the subs go off and i thought it was the fuse it was hooked to but i switched the fuse and it kept doing it so I took it off the fuse and left it off but I started driving home and the subs kept going off what could it be I need help 

Do you mean your amp is shutting off?  Like, you accelerate and the amp cuts out?  If that's the case, it sounds as if you have a loose connection and it's exacerbated by the movement from accelerating.

Yes, check all connections and report back.