Nope. Mainly to allow the manufacturer to get more money out of your wallet and into theirs. Some of them also include other "useful" features, such as some equalizer bands and such, which in certain circumstances may be of benefit to the system (note that it's the other features and not the "line driver" feature that would be the primary benefit to the system in this case). But other than that the only, ONLY, benefit to a higher preamp voltage is if you are experiencing noise in your system that can only be eliminated with either a lower gain setting or higher signal voltage level, and this is rarely the case. As helotaxi said, a higher preamp voltage improves the SNR of the signal transfer and allows for a lower gain setting. Some amplifiers can have audible noise with a high gain setting, so increasing the preamp voltage allows the user to lower the gain and eliminate the noise issue. But with modern amplifier designs, this is pretty much a non-issue in most situations. Or if there is a high noise floor during the signal transfer, increasing the voltage of the signal increases the SNR of the signal. But again, this is rarely the case and in most cases routing signal cables away from noisy areas in the vehicle will solve the issue. The gain (or input sensitivity) knob is on the amplifier to allow the amplifier to output full power with a wide range of input voltages. The gain knob basically adjusts the level of the input signal so that it will effectively "see" the same amount of input voltage. Rather you start at 2V or start at 8V, if you properly set the gain the amplifier won't know the difference and it will output the same amount of power in either circumstance. If you properly set the gain, there would be no difference in output levels between a 2V headunit and an 8V headunit. Now, what happens if you start with a 2V HU and then switch to an 8V HU but don't readjust the gain? The amplifier is set to adjust the input signal based on an expected 2V of input signal. But you are now sending it 8V, so it's not properly adjusting the level of the input signal. It's receiving a lot more than it was expecting to see. As a result, it's going to output more power because it's letting too much of the input signal pass through to the amplification stage. This means the amplifier is going to output more power with the gain set to the 2V setting and an 8V input signal than it would with a 2V setting and 2V of input signal. In order for the amplifier to properly adjust the input signal for the higher 8V input signal, the gain would need to be reset to the 8V setting. Now you might be thinking "Hey, cool, if I don't readjust the gain that means I can get a lot more power out of my amplifier then, right?" No, this is bad. This is bad because the amplifier is going to amplify the input signal too much and clip the signal it is outputting to your speakers or subwoofers. This clipped signal contains more average power than the amplifier operating below clipping (with a properly set gain), and as a result could potentially damage your speakers or subwoofers depending on the circumstance.