You could have cancellation issues, but you will only be able to find this out via measurements.
The issue here is once you load the enclosure and driver into the vehicle, the cabin becomes another air spring on the driver. When you open a window or door, the pressure is reduced or relieved and the driver can move further, which means more air is excited which means more boom boom. Some systems are just so ridiculous, that they overcome this affect with sheer power. It's akin to overcoming speed limited drag by increasing power.